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Free-energy landscapes of DNA and its assemblies:Perspectives from coarse-grained modellingJonathan P. K. Doye, Ard A. Louis, John S. Schreck, Flavio Romano,Ryan M. Harrison, Majid Mosayebi, Megan C. Engel, Thomas E. Ouldridgein Energy Landscapes of Nanoscale Systems, Ed. D.J. Wales, Volume 21 of the Frontiers of Nanoscience series (Elsevier), Chapter 9, pp 195-210 (2022)AbstractThis chapter will provide an overview of how characterizing free-energy landscapes can provide insights into the biophysical properties of DNA, as well as into the behaviour of the DNA assemblies used in the field of DNA nanotechnology. The landscapes for these complex systems are accessible through the use of accurate coarse-grained descriptions of DNA. Particular foci will be the landscapes associated with DNA self-assembly and mechanical deformation, where the latter can arise from either externally imposed forces or internal stresses.The chapter is available from ScienceDirect. Here are the volume and book webpages. The series webpage is here. The volume is dedicated to Professor Roy L. Johnston, who was formerly Co-Editor of the Frontiers of Nanoscience series, and who passed away in 2019. The chapter is also available from arXiv. |